The
Ads for Adobe PDF Desktop application is now available for
high-volume PDF publishers.
The application allows publishers to select groups of PDFs and folders containing PDFs on your Windows XP® system for "unattended upload and ad-enablement" via the Ads for Adobe PDF service.

I feel like I've written exhaustively on the Yahoo (YPN) and Adobe Ads for PDF program here at Website Magazine. I would be interested to know how many content publishers are using the service and the revenue they have generated from participating as well as the performance of ads appearing in these PDFs.
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Yahoo and Adobe to Offer Online Ads in PDFs (11-29-07)
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Adobe/YPN: Don't Expect Much (12-06-08)
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Update on Yahoo/Adobe and WM - Thumbs Up (1-4-08)
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Adobe Ads for PDF - How It Looks (1-22-08)
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Ads for Adobe PDF (YPN) Open (3-12-08)